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Latest erectile dysfunction News By Ernie Mundell and Robert Preidt HealthDay ReportersFRIDAY, July 9, 2021 buy levitra uk online (HealthDay News) – The air people breathe – and how much pollution is in it – may make a cheap levitra online difference in their outcomes when infected with erectile dysfunction treatment, a new study finds. Researchers found that living in more polluted areas -- including near sewage water dischargers and in close proximity to heavy traffic -- was linked with a greater likelihood of being admitted to the intensive care unit and more likelihood of needing mechanical ventilation after with erectile dysfunction. "The key takeaway is that living in a more polluted neighborhood is an independent risk factor for severity of erectile dysfunction treatment disease," said study author Dr. Anita Shallal, from cheap levitra online the Henry Ford Hospital in Detroit.

According to the American Lung Association, Detroit is the 12th most polluted city in the United States, measured by year-round fine particle pollution. Because low-income and minority populations often live in more polluted areas, the study also "calls attention to the systemic inequalities that may have led to the stark differences in erectile dysfunction treatment outcomes along racial and ethnic lines," Shallal said. "Communities of color are more likely to be located in areas closer to industrial pollution, and to cheap levitra online work in businesses that expose them to air pollution." The new research is to be presented Thursday during the online annual meeting of the European Congress of Clinical Microbiology &. Infectious Diseases.

Dr. Theodore Maniatis, medical director at Staten Island University Hospital in New York City, said the findings "make perfect sense." He said that cheap levitra online the lungs work in a "delicate balance" that's easily compromised by dirty air. Anything that upsets that balance "will likely increase the risk of pulmonary s and decrease the lungs' ability to clear such s," said Maniatis, who wasn't involved in the new study. In the study, Shallal's team collected data on where participants lived as well as data from the Environmental Protection Agency and other sources on local levels of pollutants including PM2.5, ozone, and lead paint.

They used this data to explore associations between erectile dysfunction treatment outcomes and exposure to a cheap levitra online variety of pollutants. The results. erectile dysfunction treatment patients who lived in areas with higher levels of PM2.5 and lead paint were more likely to require mechanical ventilation and be admitted to the ICU, compared to those living in less polluted neighborhoods. In fact, each small increase in long-term PM2.5 exposure cheap levitra online was associated with more than three times the odds of being mechanically ventilated and twice the likelihood of a stay in ICU.

However, it was not associated with a greater risk of dying, the study team reported. They note that the study couldn't prove cause-and-effect, only that pollution was associated with worse erectile dysfunction treatment outcomes. The researchers also found greater risks for patients who were male, black, obese or with severe long-term health cheap levitra online conditions. They were much more likely to need mechanical ventilation and to be admitted to the ICU.

Being male, obese or having severe long-term health conditions were also predictors of death following admission, according to the study. Speaking in a meeting news release, Shallal said it's not yet clear "how air pollutants contribute to more severe disease." But she theorized that "it's possible that long-term exposure to air pollution may impair the immune system, leading both to increased susceptibility to levitraes and to more severe viral s." Added to that, "fine particles in air pollution may also act cheap levitra online as a carrier for the levitra, increasing its spread," Shallal said. "Urgent further research is needed to guide policy and environmental protection, to minimize the impact of erectile dysfunction treatment in highly industrialized communities that are home to our most vulnerable residents." Dr. Irene Galperin is chief of pulmonary medicine at Long Island Jewish Forest Hills, in New York City.

Reading over the findings, she cheap levitra online noted that "inhalation of fine particulate matter can lead to chronic inflammation, reduced immune response and diminished ability of the lung to heal and repair itself." Galperin said that, "based on this latest study, [it's possible that] patients with history of such exposure are more likely to develop severe erectile dysfunction treatment 19 illness." Experts note that findings presented at medical meetings are considered preliminary until published in a peer-reviewed journal. More information The National Institute of Environmental Health Sciences has more on pollution and health. SOURCES. Theodore Maniatis, MD, medical director, Staten Island cheap levitra online University Hospital, New York City.

Irene Galperin MD, chief, pulmonary medicine, Long Island Jewish Forest Hills, New York City. European Congress of Clinical Microbiology &. Infectious Diseases, news release, July 8, 2021 Copyright cheap levitra online © 2021 HealthDay. All rights reserved.Latest erectile dysfunction News FRIDAY, July 9, 2021 (HealthDay News) Why do some people infected with erectile dysfunction have either no or negligible symptoms, while others sicken and die?.

Scientists who've pinpointed several genetic markers associated with severe erectile dysfunction treatment say their findings could provide answers to that important question -- and targets for future treatments. The investigators spotted 13 locations in human DNA that are strongly associated with erectile dysfunction or cheap levitra online severe erectile dysfunction treatment. The international team of researchers also identified non-genetic risk factors, such as smoking and obesity. The results are from one of the largest genome-wide association studies ever conducted.

It included nearly 50,000 erectile dysfunction treatment patients and a control cheap levitra online group of 2 million uninfected people. Locations associated with severe erectile dysfunction treatment include. The FOXP4 gene, which is linked to lung cancer. The DPP9 gene, associated cheap levitra online with lung cancer and pulmonary fibrosis.

And the TYK2 gene, which is connected with some autoimmune diseases. Inhibiting such genes could be potential treatments for preventing severe erectile dysfunction treatment, according to the authors of the study published online July 8 in the journal Nature. The research is from the erectile dysfunction treatment Host Genomics Initiative, which currently includes more than 3,300 authors cheap levitra online and 61 studies from 25 countries. While treatments protect against , treatment for erectile dysfunction treatment could be significantly improved and that can be guided by genetic analysis, said study co-senior author Ben Neale.

He is co-director of the Program in Medical and Population Genetics at the Broad Institute of MIT and Harvard, in Cambridge, Mass. Improved treatments could help shift the erectile dysfunction treatment levitra to a disease that is more localized and present at consistent, but cheap levitra online low, levels — much like the flu, according to Neale. "The better we get at treating erectile dysfunction treatment, the better equipped the medical community could be to manage the disease," Neale said in an institute news release. "If we had a mechanism of treating and getting someone out of the hospital, that would radically alter our public health response." The researchers will continue to study more data to try to determine what differentiates so-called "long haulers" — patients whose erectile dysfunction treatment symptoms persist for months — from others, and to identify additional loci associated with and severe disease.

Mark Daly is erectile dysfunction treatment Host Genomics Initiative co-founder, director of the Institute for Molecular Medicine Finland, University of Helsinki, and a member at the cheap levitra online Broad Institute. Daly said, "We'd like to aim to get a good handful of very concrete therapeutic hypotheses in the next year. Realistically, we will most likely be addressing erectile dysfunction treatment as a serious health concern for a long time. Any therapeutic that emerges this year, for example from repurposing an cheap levitra online existing drug based on clear genetic insights, would have a great impact." More information The U.S.

Centers for Disease Control and Prevention has more on erectile dysfunction treatment. SOURCE. Broad Institute of MIT and Harvard, news release, July 8, 2021 Robert Preidt Copyright cheap levitra online © 2021 HealthDay. All rights reserved.Latest Healthy Kids News FRIDAY, July 9, 2021 (HealthDay News) Could your children's eating habits be a reflection of their personalities?.

A new study finds a link between the two, but researchers say it's not clear exactly how they influence each other. They found that slow eaters are less likely to be extroverted and impulsive, and that youngsters who are highly responsive to external food cues -- the urge to eat when food is seen, smelled or tasted -- have higher cheap levitra online rates of frustration, discomfort and difficulty self-soothing. Another finding was that children who respond well to feeling full tend to have more self-control. The study included 28 people who signed up for a family intervention program to reduce eating speed among 4- to 8-year-old children.

This research is important because faster eating and higher responsiveness to food cues have been connected to obesity risk in children, said study co-author Myles Faith, professor of cheap levitra online counseling, school and educational psychology at the University of Buffalo's Graduate School of Education. "This study established relationships between temperament and eating patterns in children. However, there is still the question of chicken-and-egg and which comes first?. " Faith said in a university news release cheap levitra online.

"Research that follows families over time is needed to untangle these developmental pathways." "Temperament is linked to many child developmental and behavioral outcomes, yet despite emerging evidence, few studies have examined its relationship with pediatric obesity," said co-lead investigator Dr. Robert Berkowitz, director of the Weight and Eating Disorders Research Program at Children's Hospital of Philadelphia. More research is needed to understand the role parents play in their children's temperament and eating behavior, said study co-lead investigator and first author Alyssa Button, a doctoral candidate in the University of Buffalo's Graduate School of Education, and senior research support specialist in the department of pediatrics in the cheap levitra online university's School of Medicine and Biomedical Science. "Parents may use food to soothe temperamental children and ease negative emotions," Button said in the release.

"Future research should examine the different ways parents feed their children in response to their temperament, as well as explore whether the relationship between temperament and eating behaviors is a two-way street," she noted. "Could the habit of eating slower, over time, cheap levitra online lead to lower impulsiveness?. " The study was published in the June issue of the journal Pediatric Obesity. More information The American Academy of Pediatrics offers resources on child nutrition.

SOURCE. University at Buffalo, news release, July 7, 2021 Robert Preidt Copyright © 2021 HealthDay. All rights reserved. SLIDESHOW Childhood Diseases.

Measles, Mumps, &. More See SlideshowLatest erectile dysfunction News FRIDAY, July 9, 2021 (HealthDay News) A double dose of China's CoronaVac treatment is 83.5% effective against symptomatic erectile dysfunction treatment, researchers say. Their phase 3 trial included more than 10,000 people, aged 18 to 59, in Turkey who received either two doses of CoronaVac 14 days apart or an inactive placebo. An immune response analysis of 981 participants who got the treatment found that it triggered a strong immune response in 90%, the study authors said.

"In order to bring the erectile dysfunction treatment levitra under control, the world needs every single dose of safe and effective treatments, and our results add important evidence of the safety and effectiveness of inactivated-levitra treatments," said researcher Murat Akova of Hacettepe University Medical School, in Turkey. In the trial, there were no severe adverse events associated with the treatment, and most adverse events (90%) were mild. They included fatigue, injection site pain and muscle aches. The trial was conducted between Sept.

14, 2020 and Jan. 5, 2021. The preliminary findings were published July 8 in The Lancet and are scheduled to be presented during a virtual meeting of the European Congress of Clinical Microbiology &. Infectious Diseases, held July 9 through 12.

The researchers said further study is needed to confirm the treatment's long-term effectiveness. That's because this trial had a short follow-up period, relatively young and low-risk participants, and it took place before variants of concern appeared. Developed by Sinovac Life Sciences, CoronaVac uses an inactivated, harmless levitra that prompts the immune system to produce antibodies, according to a journal news release. The treatment has been approved for emergency use in 22 countries, and has been in phase 3 trials in Brazil, Indonesia, Chile and Turkey since mid-2020.

Akova said CoronaVac has an important advantage over some other erectile dysfunction treatments. "One of the advantages of CoronaVac is that it does not need to be frozen, making it easier to transport and distribute," Akova said. "This could be particularly important for global distribution, as some countries may struggle to store large amounts of treatment at very low temperatures." Maheshi Ramasamy of the University of Oxford in England, and Lucy Jessop of the National Immunisation Office of the Health Service Executive in Ireland, wrote an editorial published along with the study results. The findings "suggest that two doses of CoronaVac have robust efficacy (within the WHO target product profile for erectile dysfunction treatments) and acceptable tolerability when administered with a 14-day interval," they wrote.

The editorialists noted that the availability of CoronaVac in single-dose vials reduces waste and makes it easy to administer. "CoronaVac is another useful tool in the global fight against erectile dysfunction treatment, although more data are needed on its efficacy against emerging variants and on its duration of protection across different age groups and geographical settings and in the presence of comorbidities," the editorial concluded. More information The U.S. Centers for Disease Control and Prevention has more on erectile dysfunction treatments.

SOURCE. The Lancet, news release, July 8, 2021 Robert Preidt Copyright © 2021 HealthDay. All rights reserved.Latest Sleep News FRIDAY, July 9, 2021 (HealthDay News) Groggy?. Grumpy?.

Depressed?. Just a few nights of poor sleep can take a big toll on your mental health, a new study confirms "Many of us think that we can pay our sleep debt on weekends and be more productive on weekdays," said lead author Soomi Lee, an assistant professor in the School of Aging Studies at the University of South Florida. "However, results from this study show that having just one night of sleep loss can significantly impair your daily functioning," Lee said in a university news release. The researchers assessed the effects of getting less six hours of sleep a night, which experts say is the minimum that average adults require for optimal health.

The study included nearly 2,000 middle-aged U.S. Adults who were relatively healthy and well-educated. They recorded their mental and physical health in a diary for eight straight days. About four in ten (42%) had at least one night of sleep loss, sleeping 1.5 fewer hours than their typical amount.

Sleep loss resulted in negative emotions such as anger, nervousness, loneliness, irritability and frustration. Physical symptoms surfaced, too, including upper respiratory issues, aches and gastrointestinal problems. These mental and physical issues remained elevated until participants had a night's sleep of more than six hours, according to the study. The largest increase in symptoms occurred after just one night of sleep loss and steadily got worse until day three, said Lee.

After that point, the body gets relatively used to repeated sleep loss, Lee said. But on day six, sleep-deprived participants reported that the severity of their physical symptoms was at its worst. Previous research by Lee found that losing just 16 minutes of sleep can harm job performance. Lee's work also showed that minor sleep loss can decrease daily mindfulness, which is critical for managing stress and maintaining healthy routines.

About one-third of U.S. Adults sleep less than six hours a night. If that becomes a habit, it's increasingly difficult for your body to fully recover from lack of sleep, according to Lee. The findings were reported July 5 in the Annals of Behavioral Medicine.

More information The U.S. National Heart, Lung, and Blood Institute offers a guide to healthy sleep. SOURCE. University of South Florida, news release, July 6, 2021 Robert Preidt Copyright © 2021 HealthDay.

All rights reserved. SLIDESHOW Sleep Disorders.

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In October 2019 the icebreaker RV Polarstern sat trapped in useful reference thick sea levitra online canada ice atop the central Arctic Ocean—the only landmark in a vast expanse of nothingness. Another icebreaker, the Akademik Fedorov, approached it slowly, hauling a load of supplies and personnel. Scientists and crew lined the balconies of each ship, gripping the ice-crusted banisters as they peered across the void levitra online canada.

They could see the smiling faces of their colleagues just feet away—but they were two time zones apart. At the North Pole, 24 time zones collide at a single point, rendering them meaningless. It’s simultaneously all of Earth’s time zones and none levitra online canada of them.

There are no boundaries of any kind in this abyss, in part because there is no land and no people. The sun rises and sets just once per year, so “time of levitra online canada day” is irrelevant as well. Yet there rests the Polarstern, deliberately locked in ice for a year to measure all aspects of that ice, the ocean beneath it and the sky above.

The ship is filled with 100 people from 20 countries, drifting at the mercy of the ice floe, farther from civilization than the International Space Station. I’ve been supporting communications for the mission remotely from landlocked Colorado, where time is stable levitra online canada. My world is a bewildering contrast to the alien one the ship’s scientists are living and working in—where time functions and feels different than anywhere else on the planet.

No Time Zones Since the expedition began last September, the Polarstern’s time zone has shifted more than a dozen times. When the Akademik Fedorov and Polarstern parked side by side, they were still levitra online canada hours apart. But with no other people within hundreds of miles in all directions and with no cues from the permanently dark sky, the very concept of a time “zone” seemed meaningless.

At Earth’s other pole, time zones are quirky but levitra online canada rooted in utility. In Antarctica there is land and dozens of research stations scattered across thousands of square miles. At most stations, permanent buildings house laboratories, living quarters and social spaces.

Each mini civilization has adopted its own time zone that corresponds with the home territory that levitra online canada built each place. At the North Pole, it’s all ocean, visited only rarely by an occasional research vessel or a lonely supply ship that strayed from the Northwest Passage. Sea captains choose their own time in the central Arctic.

They may maintain the time zones of bordering countries—or levitra online canada they may switch based on ship activities. Sitting here in my grounded office, it is baffling to think about a place where a single human can decide to create an entire time zone at any instant. Last fall the Polarstern captain pushed the time zone levitra online canada back one hour every week, for six weeks, to sync up with incoming Russian ships that follow Moscow time.

With each shift, the captain adjusted automatic clocks scattered around the ship. Researchers paused to watch the hands of analog clocks spin eerily backward. And every time the time changed, it jostled the delicate balance of clock-based communication—between levitra online canada instruments deployed on the ice, between researchers onboard, and between them and their families and colleagues on faraway land.

No Time If drifting without established time zones isn’t alienating enough for people onboard, add the unsettling reality that there is no time of day either. What we think of as a single day, flanked by sunrise and levitra online canada sunset, happens just once per year around the North Pole. So I can’t help but wonder.

Does a single day up North last for months?. Is a levitra online canada year just a day long?. The Polarstern was engulfed by darkness in October after a three-week-long sunset—just as the other pole saw the first bits of a three-week sunrise after months of black.

Once polar night takes over, there is only relentless darkness. Looking out from the ship's deck, a person sees a horizonless cavity—unless it is levitra online canada dotted by needles of light spouting from the headlamps of a couple of distant human beings at work—an otherworldly scene not unlike being on the moon. Inside the ship is just as bizarre.

How can 100 people function levitra online canada if there is no day, no night, no morning, no evening?. The voice of the German ship captain blasting over an intercom system is the sound of a wake-up call at 8 A.M.—whenever “8 A.M.” happens to be. People file into the mess hall for meals, held at predetermined intervals.

Scientists head out to the levitra online canada ice to check on equipment or meet in laboratories at equally rigid periods. The ship operates like a windup toy, disconnected from the spinning of the planet, which normally dictates time. €œTime” is just an operational ritual, intended to create the illusion of regularity.

When scientists’ fingers are warm enough, they may occasionally send a limited satellite text to their bustling levitra online canada worlds far away. Communication with friends and colleagues who are in dozens of time zones involves convoluted time conversions—a reminder that the people on the ship are in suspended animation. A fleeting text message is only a momentary connection to a levitra online canada distant existence.

Weeks and months blur together. There’s no television, no news, no people passing by. Holidays come levitra online canada and go without festive displays in supermarkets or incessant holiday songs on car radios.

The very concept of “December” feels fabricated. Each repetition of the operational rituals between subsequent periods of sleep feels identical, like living the same “day” again and again. The only levitra online canada thing that truly reminds the team that time still ticks forward is data collection.

Research instruments dot the frozen landscape around the ship, collecting measurements of the ice, the ocean, the sky—all on Coordinated Universal Time, which is based, ironically, on the position of the sun relative to Earth. The science, however, progresses levitra online canada undisturbed. Data collection has followed its own time since the Polarstern shoved off last September, liberated from the mental whiplash the humans endure.

For the people onboard, monitoring the ever progressing data gives them a sense of the forward arrow of time. Otherwise, that levitra online canada sense can only come with facial hair that grows—and with the smell of fresh bread. When the odor wafts through the ship, it must be “Sunday.” When scientists leave the Polarstern, they experience true timelessness.

Some instruments are set up miles away on the levitra online canada ice, reachable only by helicopter. It’s so dark during the flights that researchers looking out the window can’t tell how far away the ground—or rather the ice floating on the ocean—is. The helicopter drops them on the surface and takes off again, the sound of whirring blades fading into the distance.

Then it’s true levitra online canada silence. All sense of time is irrelevant. Researchers may be huddled together, their headlamps creating a tiny pool of light in the blackness, like astronauts floating in space.

Their head is heavily bundled from the levitra online canada cold, so all they hear is the beating of their own heart. That rhythm becomes the only tangible measure to track the passing of time. A polar bear guard stands watch as the researchers work, trying to scan the horizon for levitra online canada danger.

The polar bear, the animal that actually patrols the dark, frozen landscape, has no concept of time either. Maybe the bear feels only the pulse of Earth as it spins. What Matters May Be Experience My first of only a levitra online canada few calls from Colorado to the ship involved weeks of planning and trying and failing to connect with a satellite dish up there that could be blown over or buried under snow at any moment.

When I finally made a connection, I held my breath and listened to a faint ring, then a long, cold pause. The muffled, husky voice of a Russian radio attendant answered, “RV Polarstern, this is Igor.” A few weeks later I worked to organize a San Francisco–based press conference for the expedition. Our goal levitra online canada.

Connect journalists with ship-based researchers by phone in real time. Logistics meant connecting with colleagues in five time zones on land while trying to nail down the “time” of a ship that could drift into another time zone levitra online canada at any instant. It felt like throwing darts blindfolded at a moving target.

We pulled it off, and soon after I was on a plane home. When the wheels hit the tarmac, levitra online canada I grabbed my phone to text my husband that I had landed safely. When I toggled off airplane mode, I saw the time jump from 8 P.M.

To 9 P.M. In an levitra online canada instant. Time is weird everywhere.

Maybe time is defined not by numbers levitra online canada or zones or the spinning of Earth—but by what we experience. When I entered my house, I was eagerly greeted by my dogs. I fed them their dinner—their favorite “time” of day.

Right about then, researchers on the ship were eating a bowl of warm oats before hitting the ice—“time” to check those instruments again.By century’s end, tens of millions of U.S levitra online canada. Coastal property owners will face a decision embodied in the popular exhortation, “Move it or lose it.” But there’s an option for people who can’t imagine a home without an ocean view. It’s called “seasteading,” and it could be a 21st-century antidote to the levitra online canada nation’s disappearing shorelines.

€œFloating cities” could become climate havens for people whose lives and livelihoods are tethered to the sea or nearby coast, according to the San Francisco-based Seasteading Institute. In many cases, floating colonies would be populated by people whose homes are rendered uninhabitable by rising seas and storm surges that chew away at the edge of the continent. Residents would live in levitra online canada modern homes built atop modular platforms that rise and fall with the tides.

Some communities could be linked to the mainland by bridges and utility lines. Others could exist miles offshore as semiautonomous cities or even independent nations. €œNearly half the world’s surface is unclaimed by any nation-state, and many coastal nations can levitra online canada legislate seasteads in their territorial waters,” says the Seasteading Institute, which has embraced floating cities with a near-religious fervor.

A few would occupy converted cruise ships flying under independent flags. Others would levitra online canada look like condominium complexes built atop ocean freighters or barges. All will provide offshore refuge from traditional seaside communities where climate hazards are becoming a part of daily life.

As an added benefit, floating cities could enjoy a limitless supply of desalinated water, while homes and businesses would be powered by microgrids pulsing with wind and solar energy. Transportation would require little more than two feet or two wheels, levitra online canada and be entirely carbon-free. In deeper water, floating cities could rely on aquaculture, hydroponics and rooftop gardens.

Other essentials could be delivered by barge or ship. It’s a tough sell, often punctuated by levitra online canada eye rolls. €œThe thing I usually hear when I first talk about this is, ‘Oh, you want to build ‘Waterworld,’” said landscape architect and seasteading advocate Greg Delaune, referring to the 1995 postapocalyptic film starring Kevin Costner as a kind of Mad Max of the sea.

€œYou know, that’s not really the image we want people to conjure up, but it’s often the first thing that comes to levitra online canada their minds. I get it,” added Delaune, who recently co-founded the Deep Blue Institute, a Louisiana-based organization dedicated to building marine-based resilient communities. Delaune is convinced that southeast Louisiana—one of the fastest-sinking coastlines in the world—could be a U.S.

Prototype for such a community, where floating structures—homes, businesses, parks and marinas—would offer a more stable life than levitra online canada a sinking marsh. When hurricanes and storms threaten, as is increasingly common on the fast-warming Atlantic Ocean and Gulf of Mexico, modular floating cities could be partly disassembled and moved into safe harbor or to calmer waters, proponents say. The details of how that would happen remain sketchy.

But ship-based communities levitra online canada already have the luxury of movement, and back-bay communities would garner some protection from the ocean shore. Futuristic as it sounds, seasteading is not new, and its adaptability to the United States is already being tested through other human-inhabited offshore infrastructure. The Dutch model Oil and gas platforms host levitra online canada hundreds of workers for months at a time.

And as energy companies migrate into deeper water, floating platforms are becoming the norm. For proof, cross the Atlantic Ocean to the Netherlands, a climate-threatened country whose fate is tied to the sea. €œThe Dutch have levitra online canada been doing this for 400 to 500 years.

Now they’re selling their ideas around the world,” Delaune said. €œI see no reason why we can’t design and build sustainable, resilient sea-based communities right here, borrowing on some of the same marine-resilient infrastructure that made the United States levitra online canada a leader in these other offshore activities.” Experts say the origins of floating cities also lie in the Netherlands, where Dutch engineers have spent centuries adapting to life at the ocean’s doorstep. Much of the western half of the country is below sea level, and Amsterdam, with a population of 1.1 million, is nearly 7 feet below the adjoining North Sea.

The Dutch way of coastal adaptation, distilled in the phrase “living with water,” has informed urban planning in waterfront cities around the world, notably its use of highly engineered infrastructure like dikes, dams and floodgates. The Army Corps of Engineers incorporated such approaches into the redesigned Southeast Louisiana Urban Flood Control levitra online canada Project built after Hurricane Katrina. Lesser known but gaining notoriety are the floating homes developed over the last two decades around Amsterdam, one of the lowest-lying cities in the world.

They include IJburg, a planned residential district east of Amsterdam where more than 120 floating homes will make up “Waterbuurt West,” a floating suburb on an inland bay called the IJ. When fully developed, IJburg will support levitra online canada 18,000 floating homes for 45,000 people. But what of the United States, where cities like Boston, New York, Miami, Houston and New Orleans are equally threatened by storm surges and rising seas?.

Experts say it’s a slow process, in part levitra online canada because much of the coastal adaptation conversation has focused on shoreline protection, home elevations and coastal retreat. €œThe Dutch have this mentality that we can experiment. The U.S.

Mentality is we can’t change anything,” said Dale Morris, director of strategic partnerships at the Water Institute of the Gulf, a national nonprofit based levitra online canada in Baton Rouge, La., that provides research and technical support to communities preparing for sea-level rise and other climate change impacts. For eight years after Katrina, Morris worked for the Dutch government as a liaison to Louisiana and other coastal states facing challenges around water management, flood control and climate adaptation. Morris is an advocate for floating cities in the United States, but he is also a realist.

In an interview, he said floating cities are impeded levitra online canada by social, political, economic and cultural barriers. Among them are the long-standing American ideals of abundant land and natural resources, and the notion that people can spread out as cities become denser, dirtier and more expensive. That hasn’t levitra online canada happened.

Today, 95 million Americans, nearly 30% of the U.S. Population, live in coastline counties, according to the Census Bureau, compared with roughly 80 million people in 2000. Coastal cities also experience some of the most disruptive and levitra online canada costly climate change impacts, as evidenced by the frequency of tropical storms like Superstorm Sandy and Hurricane Harvey, which hit two of the nation’s largest urban areas.

Other hazards include peak rain events, or “rainbombs,” that quickly overwhelm urban infrastructure. And while storm surge flooding from hurricanes is catastrophic and occasional, king tides and sunny-day flooding can occur daily and are equally damaging to low-lying cities, experts say. €œThere are visionaries who are investing in these important ideas, and the technology that allows us levitra online canada to do innovative things is improving all the time,” Morris said.

€œBut the economic components of these ideas have to be addressed. There’s an iterative process between vision and reality.” But, Morris noted, “it’s also true that without inspiration or vision, there is no progress.” Big ideas, big failures That’s where advocates have their work cut out for levitra online canada them. In the United States, much of the enthusiasm for floating cities is channeled through the Seasteading Institute, which was founded by Patri Friedman, an entrepreneur and grandson of the Nobel Memorial Prize-winning economist Milton Friedman, also a libertarian.

Friedman and colleague Joe Quirk, the institute’s president, wrote the bible of floating cities, titled “Seasteading. How Floating Nations Will Restore the Environment, Enrich the Poor, Cure the Sick, and Liberate Humanity from Politicians.” In it, they say “seasteaders are radically misunderstood by landlubbers.” Quirk did not make himself available for an interview, but in an email to E&E News, he said, “Not only is seasteading the quickest, cheapest solution to sea-level rise, we will increase the amount of life on the ocean with every seastead we build.” While not a developer, the institute is a portal for levitra online canada information and advocacy materials, including research papers, blogs, podcasts and YouTube videos explaining and extolling the virtues of floating human habitation. Its website also provides a list of “active” seasteading projects.

Quick also co-created Blue Frontiers, a company that worked with French Polynesia in 2017 to establish a semiautonomous floating city off the Pacific levitra online canada island nation. With pilot costs estimated at between $30 million and $50 million, the project gained significant momentum before it was postponed indefinitely by the government for political reasons, according to the firm. Most floating cities are overseas, but the institute’s list includes Delaune’s effort—called the “Louisiana Opportunity Zone Initiative,” or “Blue Tech Delta”—as well as several projects that remain under development or did not materialize.

One in California called Ventive SeaTech aims “to build permanent ocean communities for the masses, using modular structures designed to make ocean living safe, comfortable and affordable.” Its primary product, the “floathouse,” is shaped like levitra online canada a capsule with windows. It’s described as “a finished home, ready to move in, and is intended to be a year-round home for individuals or a family” by Ventive SeaTech. Another long-awaited project, conceived in 2011 by a California firm called Blueseed, would establish a floating city on a cruise ship parked in international waters about 12 miles offshore from San Francisco.

Its developers describe it an “entrepreneurial incubator” and “the Googleplex of the sea,” where international tech startups could collaborate on projects near Silicon Valley without obtaining visas to enter the United States levitra online canada. It raised several million dollars in seed money, including from the well-known tech financier Peter Thiel, but it has been mothballed for six years. Where Blueseed stumbled early, levitra online canada another cruise ship city that was set to sail this month imploded days before leaving dry dock.

The MS Satoshi, conceived as a Bitcoin-based technology hub anchored in the Gulf of Panama, was rerouted to a scrap yard in India after its owner, Ocean Builders, could not find an insurer to underwrite the floating city. In a statement, Ocean Builders said it had “hit the roadblock of having no insurance company willing to insure the MS Satoshi upon dropping anchor in the Gulf of Panama. The closest we came was a company toying with us with a million dollar premium for a maximum of $5 million in coverage, nothing close to the coverage we would need to be legally compliant.” The company said it will issue refunds for levitra online canada 100 cabins it auctioned last month for between $50,000 and $100,000 each.

For U.S.-based seasteaders like Delaune, the bridge to a floating city could be years, or even decades, away. But he is not discouraged. Since arriving in New Orleans, levitra online canada he has been canvassing the region for receptive audiences.

He has found a few, including at the Tulane University School of Architecture, where a primary research effort is focused on implementing ideas that emerged a decade ago through the city’s water management planning process called the “Dutch Dialogues.” “I have my pitch deck, and I’ve been rolling it out down here over the last few months,” Delaune said. €œThe big spin is levitra online canada the dying wetlands east of New Orleans, the buffer areas, the barrier islands. People cannot live in these places anymore.” Delaune says the project could take years to materialize.

But as Louisiana undergoes a multibillion-dollar restoration of its coastline, floating communities can be a part of the solution. €œThese people don’t levitra online canada want a Silicon Valley or NASA project to drop into their backyards,” he said. €œBut when your people are leaving and your economy is dying, there is no plan B except to move away.” Reprinted from Climatewire with permission from E&E News.

E&E provides daily coverage of essential energy and environmental news at www.eenews.net..

In October 2019 the icebreaker RV Polarstern sat cheap levitra online trapped in thick sea ice atop the central Arctic Ocean—the only landmark in a vast expanse of nothingness. Another icebreaker, the Akademik Fedorov, approached it slowly, hauling a load of supplies and personnel. Scientists and crew lined the balconies of each ship, cheap levitra online gripping the ice-crusted banisters as they peered across the void.

They could see the smiling faces of their colleagues just feet away—but they were two time zones apart. At the North Pole, 24 time zones collide at a single point, rendering them meaningless. It’s simultaneously all of Earth’s cheap levitra online time zones and none of them.

There are no boundaries of any kind in this abyss, in part because there is no land and no people. The sun cheap levitra online rises and sets just once per year, so “time of day” is irrelevant as well. Yet there rests the Polarstern, deliberately locked in ice for a year to measure all aspects of that ice, the ocean beneath it and the sky above.

The ship is filled with 100 people from 20 countries, drifting at the mercy of the ice floe, farther from civilization than the International Space Station. I’ve been supporting communications for the mission remotely cheap levitra online from landlocked Colorado, where time is stable. My world is a bewildering contrast to the alien one the ship’s scientists are living and working in—where time functions and feels different than anywhere else on the planet.

No Time Zones Since the expedition began last September, the Polarstern’s time zone has shifted more than a dozen times. When the Akademik cheap levitra online Fedorov and Polarstern parked side by side, they were still hours apart. But with no other people within hundreds of miles in all directions and with no cues from the permanently dark sky, the very concept of a time “zone” seemed meaningless.

At Earth’s other pole, time zones are quirky but cheap levitra online rooted in utility. In Antarctica there is land and dozens of research stations scattered across thousands of square miles. At most stations, permanent buildings house laboratories, living quarters and social spaces.

Each mini civilization has adopted its own time zone that corresponds with the home territory that built each place cheap levitra online. At the North Pole, it’s all ocean, visited only rarely by an occasional research vessel or a lonely supply ship that strayed from the Northwest Passage. Sea captains choose their own time in the central Arctic.

They may maintain the time zones of bordering countries—or they may switch cheap levitra online based on ship activities. Sitting here in my grounded office, it is baffling to think about a place where a single human can decide to create an entire time zone at any instant. Last fall the Polarstern captain pushed the time zone back one hour every cheap levitra online week, for six weeks, to sync up with incoming Russian ships that follow Moscow time.

With each shift, the captain adjusted automatic clocks scattered around the ship. Researchers paused to watch the hands of analog clocks spin eerily backward. And every time the cheap levitra online time changed, it jostled the delicate balance of clock-based communication—between instruments deployed on the ice, between researchers onboard, and between them and their families and colleagues on faraway land.

No Time If drifting without established time zones isn’t alienating enough for people onboard, add the unsettling reality that there is no time of day either. What we think of as a single day, flanked by sunrise and sunset, happens just once per year cheap levitra online around the North Pole. So I can’t help but wonder.

Does a single day up North last for months?. Is a cheap levitra online year just a day long?. The Polarstern was engulfed by darkness in October after a three-week-long sunset—just as the other pole saw the first bits of a three-week sunrise after months of black.

Once polar night takes over, there is only relentless darkness. Looking out from the ship's deck, a person sees a horizonless cavity—unless it is dotted by needles of light spouting from the headlamps of a couple cheap levitra online of distant human beings at work—an otherworldly scene not unlike being on the moon. Inside the ship is just as bizarre.

How can 100 people function if there is no cheap levitra online day, no night, no morning, no evening?. The voice of the German ship captain blasting over an intercom system is the sound of a wake-up call at 8 A.M.—whenever “8 A.M.” happens to be. People file into the mess hall for meals, held at predetermined intervals.

Scientists head out to the ice to check on equipment or meet in laboratories at equally rigid cheap levitra online periods. The ship operates like a windup toy, disconnected from the spinning of the planet, which normally dictates time. €œTime” is just an operational ritual, intended to create the illusion of regularity.

When scientists’ fingers are warm enough, cheap levitra online they may occasionally send a limited satellite text to their bustling worlds far away. Communication with friends and colleagues who are in dozens of time zones involves convoluted time conversions—a reminder that the people on the ship are in suspended animation. A fleeting text message is only cheap levitra online a momentary connection to a distant existence.

Weeks and months blur together. There’s no television, no news, no people passing by. Holidays come and go without festive displays in supermarkets or cheap levitra online incessant holiday songs on car radios.

The very concept of “December” feels fabricated. Each repetition of the operational rituals between subsequent periods of sleep feels identical, like living the same “day” again and again. The only thing that truly cheap levitra online reminds the team that time still ticks forward is data collection.

Research instruments dot the frozen landscape around the ship, collecting measurements of the ice, the ocean, the sky—all on Coordinated Universal Time, which is based, ironically, on the position of the sun relative to Earth. The science, cheap levitra online however, progresses undisturbed. Data collection has followed its own time since the Polarstern shoved off last September, liberated from the mental whiplash the humans endure.

For the people onboard, monitoring the ever progressing data gives them a sense of the forward arrow of time. Otherwise, that sense can only come with facial hair that grows—and with cheap levitra online the smell of fresh bread. When the odor wafts through the ship, it must be “Sunday.” When scientists leave the Polarstern, they experience true timelessness.

Some instruments are set cheap levitra online up miles away on the ice, reachable only by helicopter. It’s so dark during the flights that researchers looking out the window can’t tell how far away the ground—or rather the ice floating on the ocean—is. The helicopter drops them on the surface and takes off again, the sound of whirring blades fading into the distance.

Then it’s true cheap levitra online silence. All sense of time is irrelevant. Researchers may be huddled together, their headlamps creating a tiny pool of light in the blackness, like astronauts floating in space.

Their head is cheap levitra online heavily bundled from the cold, so all they hear is the beating of their own heart. That rhythm becomes the only tangible measure to track the passing of time. A polar bear guard stands watch as the researchers work, trying to scan the horizon for danger cheap levitra online.

The polar bear, the animal that actually patrols the dark, frozen landscape, has no concept of time either. Maybe the bear feels only the pulse of Earth as it spins. What Matters May cheap levitra online Be Experience My first of only a few calls from Colorado to the ship involved weeks of planning and trying and failing to connect with a satellite dish up there that could be blown over or buried under snow at any moment.

When I finally made a connection, I held my breath and listened to a faint ring, then a long, cold pause. The muffled, husky voice of a Russian radio attendant answered, “RV Polarstern, this is Igor.” A few weeks later I worked to organize a San Francisco–based press conference for the expedition. Our goal cheap levitra online.

Connect journalists with ship-based researchers by phone in real time. Logistics meant connecting with colleagues in five time zones on land while trying to nail down the “time” of a ship that could drift cheap levitra online into another time zone at any instant. It felt like throwing darts blindfolded at a moving target.

We pulled it off, and soon after I was on a plane home. When the wheels hit cheap levitra online the tarmac, I grabbed my phone to text my husband that I had landed safely. When I toggled off airplane mode, I saw the time jump from 8 P.M.

To 9 P.M. In an cheap levitra online instant. Time is weird everywhere.

Maybe time is defined not by numbers cheap levitra online or zones or the spinning of Earth—but by what we experience. When I entered my house, I was eagerly greeted by my dogs. I fed them their dinner—their favorite “time” of day.

Right about then, researchers on the ship were eating a bowl of warm oats before hitting the ice—“time” to check those instruments again.By century’s end, cheap levitra online tens of millions of U.S. Coastal property owners will face a decision embodied in the popular exhortation, “Move it or lose it.” But there’s an option for people who can’t imagine a home without an ocean view. It’s called “seasteading,” and it could be cheap levitra online a 21st-century antidote to the nation’s disappearing shorelines.

€œFloating cities” could become climate havens for people whose lives and livelihoods are tethered to the sea or nearby coast, according to the San Francisco-based Seasteading Institute. In many cases, floating colonies would be populated by people whose homes are rendered uninhabitable by rising seas and storm surges that chew away at the edge of the continent. Residents would live in modern homes built atop modular platforms that rise and fall cheap levitra online with the tides.

Some communities could be linked to the mainland by bridges and utility lines. Others could exist miles offshore as semiautonomous cities or even independent nations. €œNearly half the world’s surface is unclaimed cheap levitra online by any nation-state, and many coastal nations can legislate seasteads in their territorial waters,” says the Seasteading Institute, which has embraced floating cities with a near-religious fervor.

A few would occupy converted cruise ships flying under independent flags. Others would cheap levitra online look like condominium complexes built atop ocean freighters or barges. All will provide offshore refuge from traditional seaside communities where climate hazards are becoming a part of daily life.

As an added benefit, floating cities could enjoy a limitless supply of desalinated water, while homes and businesses would be powered by microgrids pulsing with wind and solar energy. Transportation would require little more cheap levitra online than two feet or two wheels, and be entirely carbon-free. In deeper water, floating cities could rely on aquaculture, hydroponics and rooftop gardens.

Other essentials could be delivered by barge or ship. It’s a tough sell, often cheap levitra online punctuated by eye rolls. €œThe thing I usually hear when I first talk about this is, ‘Oh, you want to build ‘Waterworld,’” said landscape architect and seasteading advocate Greg Delaune, referring to the 1995 postapocalyptic film starring Kevin Costner as a kind of Mad Max of the sea.

€œYou know, that’s not cheap levitra online really the image we want people to conjure up, but it’s often the first thing that comes to their minds. I get it,” added Delaune, who recently co-founded the Deep Blue Institute, a Louisiana-based organization dedicated to building marine-based resilient communities. Delaune is convinced that southeast Louisiana—one of the fastest-sinking coastlines in the world—could be a U.S.

Prototype for such a community, cheap levitra online where floating structures—homes, businesses, parks and marinas—would offer a more stable life than a sinking marsh. When hurricanes and storms threaten, as is increasingly common on the fast-warming Atlantic Ocean and Gulf of Mexico, modular floating cities could be partly disassembled and moved into safe harbor or to calmer waters, proponents say. The details of how that would happen remain sketchy.

But ship-based communities already have the luxury of movement, and back-bay communities would garner some protection from cheap levitra online the ocean shore. Futuristic as it sounds, seasteading is not new, and its adaptability to the United States is already being tested through other human-inhabited offshore infrastructure. The Dutch model Oil and gas platforms host hundreds of workers for months at a time cheap levitra online.

And as energy companies migrate into deeper water, floating platforms are becoming the norm. For proof, cross the Atlantic Ocean to the Netherlands, a climate-threatened country whose fate is tied to the sea. €œThe Dutch have cheap levitra online been doing this for 400 to 500 years.

Now they’re selling their ideas around the world,” Delaune said. €œI see no reason why we can’t design and build sustainable, resilient sea-based communities cheap levitra online right here, borrowing on some of the same marine-resilient infrastructure that made the United States a leader in these other offshore activities.” Experts say the origins of floating cities also lie in the Netherlands, where Dutch engineers have spent centuries adapting to life at the ocean’s doorstep. Much of the western half of the country is below sea level, and Amsterdam, with a population of 1.1 million, is nearly 7 feet below the adjoining North Sea.

The Dutch way of coastal adaptation, distilled in the phrase “living with water,” has informed urban planning in waterfront cities around the world, notably its use of highly engineered infrastructure like dikes, dams and floodgates. The Army Corps of Engineers incorporated such approaches into the redesigned Southeast Louisiana Urban Flood cheap levitra online Control Project built after Hurricane Katrina. Lesser known but gaining notoriety are the floating homes developed over the last two decades around Amsterdam, one of the lowest-lying cities in the world.

They include IJburg, a planned residential district east of Amsterdam where more than 120 floating homes will make up “Waterbuurt West,” a floating suburb on an inland bay called the IJ. When fully developed, IJburg will support 18,000 floating homes cheap levitra online for 45,000 people. But what of the United States, where cities like Boston, New York, Miami, Houston and New Orleans are equally threatened by storm surges and rising seas?.

Experts say it’s a slow process, in part because much of the coastal adaptation conversation has focused on shoreline protection, home cheap levitra online elevations and coastal retreat. €œThe Dutch have this mentality that we can experiment. The U.S.

Mentality is we can’t change anything,” said cheap levitra online Dale Morris, director of strategic partnerships at the Water Institute of the Gulf, a national nonprofit based in Baton Rouge, La., that provides research and technical support to communities preparing for sea-level rise and other climate change impacts. For eight years after Katrina, Morris worked for the Dutch government as a liaison to Louisiana and other coastal states facing challenges around water management, flood control and climate adaptation. Morris is an advocate for floating cities in the United States, but he is also a realist.

In an interview, he said cheap levitra online floating cities are impeded by social, political, economic and cultural barriers. Among them are the long-standing American ideals of abundant land and natural resources, and the notion that people can spread out as cities become denser, dirtier and more expensive. That hasn’t cheap levitra online happened.

Today, 95 million Americans, nearly 30% of the U.S. Population, live in coastline counties, according to the Census Bureau, compared with roughly 80 million people in 2000. Coastal cities also experience some of the most disruptive and costly climate change impacts, as evidenced cheap levitra online by the frequency of tropical storms like Superstorm Sandy and Hurricane Harvey, which hit two of the nation’s largest urban areas.

Other hazards include peak rain events, or “rainbombs,” that quickly overwhelm urban infrastructure. And while storm surge flooding from hurricanes is catastrophic and occasional, king tides and sunny-day flooding can occur daily and are equally damaging to low-lying cities, experts say. €œThere are visionaries who are investing in these important ideas, and the technology that allows us to do innovative things is improving all the time,” Morris cheap levitra online said.

€œBut the economic components of these ideas have to be addressed. There’s an iterative process between vision and reality.” But, Morris noted, “it’s also true that cheap levitra online without inspiration or vision, there is no progress.” Big ideas, big failures That’s where advocates have their work cut out for them. In the United States, much of the enthusiasm for floating cities is channeled through the Seasteading Institute, which was founded by Patri Friedman, an entrepreneur and grandson of the Nobel Memorial Prize-winning economist Milton Friedman, also a libertarian.

Friedman and colleague Joe Quirk, the institute’s president, wrote the bible of floating cities, titled “Seasteading. How Floating Nations Will Restore cheap levitra online the Environment, Enrich the Poor, Cure the Sick, and Liberate Humanity from Politicians.” In it, they say “seasteaders are radically misunderstood by landlubbers.” Quirk did not make himself available for an interview, but in an email to E&E News, he said, “Not only is seasteading the quickest, cheapest solution to sea-level rise, we will increase the amount of life on the ocean with every seastead we build.” While not a developer, the institute is a portal for information and advocacy materials, including research papers, blogs, podcasts and YouTube videos explaining and extolling the virtues of floating human habitation. Its website also provides a list of “active” seasteading projects.

Quick also cheap levitra online co-created Blue Frontiers, a company that worked with French Polynesia in 2017 to establish a semiautonomous floating city off the Pacific island nation. With pilot costs estimated at between $30 million and $50 million, the project gained significant momentum before it was postponed indefinitely by the government for political reasons, according to the firm. Most floating cities are overseas, but the institute’s list includes Delaune’s effort—called the “Louisiana Opportunity Zone Initiative,” or “Blue Tech Delta”—as well as several projects that remain under development or did not materialize.

One in California called Ventive SeaTech aims “to build permanent ocean communities for the masses, cheap levitra online using modular structures designed to make ocean living safe, comfortable and affordable.” Its primary product, the “floathouse,” is shaped like a capsule with windows. It’s described as “a finished home, ready to move in, and is intended to be a year-round home for individuals or a family” by Ventive SeaTech. Another long-awaited project, conceived in 2011 by a California firm called Blueseed, would establish a floating city on a cruise ship parked in international waters about 12 miles offshore from San Francisco.

Its developers describe it cheap levitra online an “entrepreneurial incubator” and “the Googleplex of the sea,” where international tech startups could collaborate on projects near Silicon Valley without obtaining visas to enter the United States. It raised several million dollars in seed money, including from the well-known tech financier Peter Thiel, but it has been mothballed for six years. Where Blueseed stumbled early, another cruise ship city cheap levitra online that was set to sail this month imploded days before leaving dry dock.

The MS Satoshi, conceived as a Bitcoin-based technology hub anchored in the Gulf of Panama, was rerouted to a scrap yard in India after its owner, Ocean Builders, could not find an insurer to underwrite the floating city. In a statement, Ocean Builders said it had “hit the roadblock of having no insurance company willing to insure the MS Satoshi upon dropping anchor in the Gulf of Panama. The closest we came was a company toying cheap levitra online with us with a million dollar premium for a maximum of $5 million in coverage, nothing close to the coverage we would need to be legally compliant.” The company said it will issue refunds for 100 cabins it auctioned last month for between $50,000 and $100,000 each.

For U.S.-based seasteaders like Delaune, the bridge to a floating city could be years, or even decades, away. But he is not discouraged. Since arriving in New cheap levitra online Orleans, he has been canvassing the region for receptive audiences.

He has found a few, including at the Tulane University School of Architecture, where a primary research effort is focused on implementing ideas that emerged a decade ago through the city’s water management planning process called the “Dutch Dialogues.” “I have my pitch deck, and I’ve been rolling it out down here over the last few months,” Delaune said. €œThe big spin is the dying wetlands east of cheap levitra online New Orleans, the buffer areas, the barrier islands. People cannot live in these places anymore.” Delaune says the project could take years to materialize.

But as Louisiana undergoes a multibillion-dollar restoration of its coastline, floating communities can be a part of the solution. €œThese people don’t want a Silicon Valley or NASA cheap levitra online project to drop into their backyards,” he said. €œBut when your people are leaving and your economy is dying, there is no plan B except to move away.” Reprinted from Climatewire with permission from E&E News.

E&E provides daily coverage of essential energy and environmental news at www.eenews.net..

What if I miss a dose?

This does not apply. However, do not take double or extra doses.

Ray e levitre

This story also ran on CNN. This story can be republished for free (details). Flu season here are the findings will look different this year, as the country grapples with a erectile dysfunction levitra that has killed ray e levitre more than 172,000 people. Many Americans are reluctant to visit a ray e levitre doctor’s office and public health officials worry people will shy away from being immunized.Although sometimes incorrectly regarded as just another bad cold, flu also kills tens of thousands of people in the U.S. Each year, with the very young, the elderly and those with underlying conditions the most vulnerable. When coupled with the effects of erectile dysfunction treatment, ray e levitre public health experts say it’s more important than ever to get a flu shot.If enough of the U.S. Population gets vaccinated — more than the 45% who did last flu season — it could help head off a nightmare scenario in the coming winter of hospitals stuffed with both erectile dysfunction treatment patients and those suffering from severe effects of influenza.Aside from the potential burden on hospitals, there’s the possibility people could get both levitraes — and “no one knows what happens if you get influenza and erectile dysfunction treatment [simultaneously] because it’s never happened before,” Dr.

Rachel Levine, Pennsylvania’s secretary of health, told reporters this month.In response, manufacturers are producing more treatment supply this year, between 194 million and 198 million doses, or about 20 million more than they distributed last season, according to the Centers for Disease Control and Prevention. Email Sign-Up Subscribe to KHN’s ray e levitre free Morning Briefing. As flu season approaches, here are some answers to a few common questions:Q. When should I get my flu shot? ray e levitre. Advertising has already begun, and some pharmacies and clinics have their supplies now. But, because the effectiveness of the treatment can wane over time, the ray e levitre CDC recommends against a shot in August.Many pharmacies and clinics will start immunizations in early September. Generally, influenza levitraes start circulating in mid- to late October but become more widespread later, in the winter.

It takes about two weeks after getting a shot for antibodies — which circulate in the blood and ray e levitre thwart s — to build up. €œYoung, healthy people can begin getting their flu shots in September, and elderly people and other vulnerable populations can begin in October,” said Dr. Steve Miller, chief clinical officer for insurer Cigna.The CDC has recommended that people “get a flu treatment by the end of October,” but noted it’s not too late to get one after that because shots “can still be beneficial and vaccination should be offered throughout the flu season.”Even so, some experts say not to wait too long this year — not only because of erectile dysfunction treatment, but also in case a shortage develops ray e levitre because of overwhelming demand.Q. What are the reasons ray e levitre I should roll up my sleeve for this?. Get a shot because it protects you from catching the flu and spreading it to others, which may help lessen the burden on hospitals and medical staffs.And there’s another message that may resonate in this strange time.“It gives people a sense that there are some things you can control,” said Eduardo Sanchez, chief medical officer for prevention at the American Heart Association.While a flu shot won’t prevent erectile dysfunction treatment, he said, getting one could help your doctors differentiate between the diseases if you develop any symptoms — fever, cough, sore throat — they share.And even though flu shots won’t prevent all cases of the flu, getting vaccinated can lessen the severity if you do fall ill, he said.You cannot get influenza from having a flu treatment.All eligible people, especially essential workers, those with underlying conditions and those at higher risk — including very young children and pregnant women — should seek protection, the CDC said.

It recommends that children over ray e levitre 6 months old get vaccinated.Q. What do we know about the effectiveness of this year’s treatment?. Flu treatments — which must be developed anew each year because influenza levitraes mutate — range ray e levitre in effectiveness annually, depending on how well they match the circulating levitra. Last year’s formulation was estimated to be about 45% effective ray e levitre in preventing the flu overall, with about a 55% effectiveness in children. The treatments available in the U.S.

This year are aimed at preventing at least three strains of the levitra, and most cover four.It isn’t yet known how ray e levitre well this year’s supply will match the strains that will circulate in the U.S. Early indications from the Southern Hemisphere, which goes through its flu season during our summer, are encouraging. There, people practiced social distancing, wore masks and got vaccinated in greater numbers this year — and global flu ray e levitre levels are lower than expected. Experts caution, however, not to count on a similarly mild season in the U.S., in part because masking and social distancing efforts vary widely.Q. What are ray e levitre insurance plans and health systems doing differently this year?.

Insurers and health systems contacted by KHN say they will follow CDC guidelines, which call ray e levitre for limiting and spacing out the number of people waiting in lines and vaccination areas. Some are setting appointments for flu shots to help manage the flow.Health Fitness Concepts, a company that works with UnitedHealth Group and other businesses to set up flu shot clinics in the Northeast, said it is “encouraging smaller, more frequent events to support social distancing” and “requiring all forms to be completed and shirtsleeves rolled up before entering the flu shot area.” Everyone will be required to wear masks.Also, nationally, some physician groups contracted with UnitedHealth will set up tent areas so shots can be given outdoors, a spokesperson said.Kaiser Permanente plans drive-thru vaccinations at some of its medical facilities and is testing touch-free screening and check-in procedures at some locations. (KHN is not affiliated with Kaiser Permanente.)Geisinger Health, ray e levitre a regional health provider in Pennsylvania and New Jersey, said it, too, would have outdoor flu vaccination programs at its facilities.Additionally, “Geisinger is making it mandatory for all employees to receive the flu treatment this year,” said Mark Shelly, the system’s director of prevention and control. €œBy taking this step, we hope to convey to our neighbors the importance of the flu treatment for everyone.”Q. Usually I get a flu shot at work ray e levitre.

Will that be an option this ray e levitre year?. Aiming to avoid risky indoor gatherings, many employers are reluctant to sponsor the on-site flu clinics they’ve offered in years past. And with ray e levitre so many people continuing to work from home, there’s less need to bring flu shots to employees on the job. Instead, many employers are encouraging workers to get shots from their primary care doctors, at pharmacies or in other community settings. Insurance will generally cover the cost of the treatment.Some employers are considering offering vouchers for flu shots to their uninsured workers or those who don’t participate in the company ray e levitre plan, said Julie Stone, managing director for health and benefits at Willis Towers Watson, a consulting firm.

The vouchers could allow workers to get the shot at a particular lab at no cost, for example.Some employers are starting to think about how they might use their parking lots for administering drive-thru flu shots, said Dr. David Zieg, clinical services leader for benefits consultant Mercer.Although federal law allows employers to require employees to get flu shots, that step is typically taken only by ray e levitre health care facilities and some universities where people live and work closely together, Zieg said.Q. What are pharmacies doing to encourage people to get ray e levitre flu shots?. Some pharmacies are making an extra push to get out into the community to offer flu shots.Walgreens, which has nearly 9,100 pharmacies nationwide, is continuing a partnership begun in 2015 with community organizations, churches and employers that has offered about 150,000 off-site and mobile flu clinics to date.The program places a special emphasis on working with vulnerable populations and in underserved areas, said Dr. Kevin Ban, chief medical officer for the drugstore chain.Walgreens began offering flu shots in mid-August and is encouraging people not to delay getting vaccinated.Both Walgreens and CVS are encouraging people to schedule appointments and do paperwork online this year to minimize time spent in the stores.At CVS MinuteClinic locations, once patients have checked in for their flu shot, they must ray e levitre wait outside or in their car, since the indoor waiting areas are now closed.“We don’t have tons of arrows in our quiver against erectile dysfunction treatment,” Walgreens’ Ban said.

€œTaking pressure off the health care system by providing treatments in advance is one thing we can do.” Julie Appleby. jappleby@kff.org, @Julie_Appleby Michelle Andrews ray e levitre. andrews.khn@gmail.com, @mandrews110 Related Topics Insurance Public Health erectile dysfunction treatment Insurers treatments.

This story also ran on CNN. This story can be republished for free (details). Flu season will look different this year, as the country grapples with a erectile dysfunction levitra that has killed cheap levitra online more than How much does propecia cost with insurance 172,000 people. Many Americans cheap levitra online are reluctant to visit a doctor’s office and public health officials worry people will shy away from being immunized.Although sometimes incorrectly regarded as just another bad cold, flu also kills tens of thousands of people in the U.S. Each year, with the very young, the elderly and those with underlying conditions the most vulnerable. When coupled with the effects of erectile dysfunction treatment, public health experts say it’s more important than ever to cheap levitra online get a flu shot.If enough of the U.S. Population gets vaccinated — more than the 45% who did last flu season — it could help head off a nightmare scenario in the coming winter of hospitals stuffed with both erectile dysfunction treatment patients and those suffering from severe effects of influenza.Aside from the potential burden on hospitals, there’s the possibility people could get both levitraes — and “no one knows what happens if you get influenza and erectile dysfunction treatment [simultaneously] because it’s never happened before,” Dr.

Rachel Levine, Pennsylvania’s secretary of health, told reporters this month.In response, manufacturers are producing more treatment supply this year, between 194 million and 198 million doses, or about 20 million more than they distributed last season, according to the Centers for Disease Control and Prevention. Email Sign-Up Subscribe to KHN’s free Morning Briefing. As flu season approaches, here cheap levitra online are some answers to a few common questions:Q. When should I get my flu shot? cheap levitra online. Advertising has already begun, and some pharmacies and clinics have their supplies now. But, because cheap levitra online the effectiveness of the treatment can wane over time, the CDC recommends against a shot in August.Many pharmacies and clinics will start immunizations in early September. Generally, influenza levitraes start circulating in mid- to late October but become more widespread later, in the winter.

It takes about two weeks after getting a shot for antibodies — which cheap levitra online circulate in the blood and thwart s — to build up. €œYoung, healthy people can begin getting their flu shots in September, and elderly people and other vulnerable populations can begin in October,” said Dr. Steve Miller, chief clinical officer for insurer Cigna.The CDC has recommended that people “get a flu treatment by the end of October,” but noted it’s not too late to get one after that because shots “can still be beneficial and vaccination should be offered throughout the flu season.”Even so, some experts say not to wait too long this year — not cheap levitra online only because of erectile dysfunction treatment, but also in case a shortage develops because of overwhelming demand.Q. What are the reasons I should roll up my sleeve for this? cheap levitra online. Get a shot because it protects you from catching the flu and spreading it to others, which may help lessen the burden on hospitals and medical staffs.And there’s another message that may resonate in this strange time.“It gives people a sense that there are some things you can control,” said Eduardo Sanchez, chief medical officer for prevention at the American Heart Association.While a flu shot won’t prevent erectile dysfunction treatment, he said, getting one could help your doctors differentiate between the diseases if you develop any symptoms — fever, cough, sore throat — they share.And even though flu shots won’t prevent all cases of the flu, getting vaccinated can lessen the severity if you do fall ill, he said.You cannot get influenza from having a flu treatment.All eligible people, especially essential workers, those with underlying conditions and those at higher risk — including very young children and pregnant women — should seek protection, the CDC said.

It recommends that children cheap levitra online over 6 months old get vaccinated.Q. What do we know about the effectiveness of this year’s treatment?. Flu treatments — which must be cheap levitra online developed anew each year because influenza levitraes mutate — range in effectiveness annually, depending on how well they match the circulating levitra. Last year’s cheap levitra online formulation was estimated to be about 45% effective in preventing the flu overall, with about a 55% effectiveness in children. The treatments available in the U.S.

This year are aimed at preventing at least three cheap levitra online strains of the levitra, and most cover four.It isn’t yet known how well this year’s supply will match the strains that will circulate in the U.S. Early indications from the Southern Hemisphere, which goes through its flu season during our summer, are encouraging. There, people practiced social distancing, wore masks and cheap levitra online got vaccinated in greater numbers this year — and global flu levels are lower than expected. Experts caution, however, not to count on a similarly mild season in the U.S., in part because masking and social distancing efforts vary widely.Q. What are insurance plans and health systems doing cheap levitra online differently this year?.

Insurers and health systems contacted by KHN say they will follow CDC guidelines, which call for cheap levitra online limiting and spacing out the number of people waiting in lines and vaccination areas. Some are setting appointments for flu shots to help manage the flow.Health Fitness Concepts, a company that works with UnitedHealth Group and other businesses to set up flu shot clinics in the Northeast, said it is “encouraging smaller, more frequent events to support social distancing” and “requiring all forms to be completed and shirtsleeves rolled up before entering the flu shot area.” Everyone will be required to wear masks.Also, nationally, some physician groups contracted with UnitedHealth will set up tent areas so shots can be given outdoors, a spokesperson said.Kaiser Permanente plans drive-thru vaccinations at some of its medical facilities and is testing touch-free screening and check-in procedures at some locations. (KHN is not affiliated with Kaiser Permanente.)Geisinger Health, a regional health provider in cheap levitra online Pennsylvania and New Jersey, said it, too, would have outdoor flu vaccination programs at its facilities.Additionally, “Geisinger is making it mandatory for all employees to receive the flu treatment this year,” said Mark Shelly, the system’s director of prevention and control. €œBy taking this step, we hope to convey to our neighbors the importance of the flu treatment for everyone.”Q. Usually I cheap levitra online get a flu shot at work.

Will that be an option this cheap levitra online year?. Aiming to avoid risky indoor gatherings, many employers are reluctant to sponsor the on-site flu clinics they’ve offered in years past. And with so many people continuing to work from home, there’s less cheap levitra online need to bring flu shots to employees on the job. Instead, many employers are encouraging workers to get shots from their primary care doctors, at pharmacies or in other community settings. Insurance will generally cover the cost of the treatment.Some employers are considering offering vouchers for flu shots to their cheap levitra online uninsured workers or those who don’t participate in the company plan, said Julie Stone, managing director for health and benefits at Willis Towers Watson, a consulting firm.

The vouchers could allow workers to get the shot at a particular lab at no cost, for example.Some employers are starting to think about how they might use their parking lots for administering drive-thru flu shots, said Dr. David Zieg, clinical services leader for benefits consultant Mercer.Although federal law allows employers to require employees to get flu cheap levitra online shots, that step is typically taken only by health care facilities and some universities where people live and work closely together, Zieg said.Q. What are pharmacies doing to encourage people cheap levitra online to get flu shots?. Some pharmacies are making an extra push to get out into the community to offer flu shots.Walgreens, which has nearly 9,100 pharmacies nationwide, is continuing a partnership begun in 2015 with community organizations, churches and employers that has offered about 150,000 off-site and mobile flu clinics to date.The program places a special emphasis on working with vulnerable populations and in underserved areas, said Dr. Kevin Ban, chief medical officer for the drugstore chain.Walgreens began offering flu shots in mid-August and is encouraging people not cheap levitra online to delay getting vaccinated.Both Walgreens and CVS are encouraging people to schedule appointments and do paperwork online this year to minimize time spent in the stores.At CVS MinuteClinic locations, once patients have checked in for their flu shot, they must wait outside or in their car, since the indoor waiting areas are now closed.“We don’t have tons of arrows in our quiver against erectile dysfunction treatment,” Walgreens’ Ban said.

€œTaking pressure off the health care system by providing treatments in advance is one thing we can do.” Julie Appleby. jappleby@kff.org, @Julie_Appleby Michelle Andrews cheap levitra online. andrews.khn@gmail.com, @mandrews110 Related Topics Insurance Public Health erectile dysfunction treatment Insurers treatments.

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Federal investigators have launched a probe into a Hudson Valley police department to determine whether or not officers engaged in a pattern of discriminatory policing.US Attorney Damian Williams announced that in Westchester, the Justice Department has opened a pattern or practice investigation into the Mount Vernon Police Department.According to Williams, the investigation will assess the department’s use of force, strip and body cavity searches, look at this web-site and how it handles evidence.The investigation canadian pharmacy levitra value pack will include a comprehensive review of Mount Vernon Police Department’s systems of accountability, including complaint intake, investigation, review, disposition, and discipline.Williams said that his office and the Justice Department’s Civil Rights Division will also be reaching out to community groups and members of the public to learn about their experiences with the Mount Vernon Police Department.“Police officers have tough jobs, and so many do their work honorably, lawfully, and with distinction, respecting the rights of the citizens they have sworn to protect,” Williams said. €œBut when officers break the law, they violate canadian pharmacy levitra value pack their oath and undermine a community’s trust.” City officials in Mount Vernon were notified of the investigation on Friday, Dec. 3.“An effective and accountable police department is a hallmark of a healthy and well-functioning democracy,” Assistant Attorney General for the Civil Rights Division Kristen canadian pharmacy levitra value pack Clarke said. €œThe Civil Rights Division is committed to ensuring that law enforcement agencies across our country use their authority canadian pharmacy levitra value pack in a manner that is constitutional, transparent, and free from discrimination.”According to Williams, “the investigation is being conducted pursuant to the Violent Crime Control and Law Enforcement Act of 1994, which prohibits state and local governments from engaging in a pattern or practice of conduct by law enforcement officers that deprives individuals of rights protected by the Constitution or federal law.” Anyone who has information relevant to the investigation into the Mount Vernon Police Department has been asked to contact the Department of Justice at community.mvpd@usdoj.gov or to call (866) 985-1378."I commend the Department of Justice and the Southern District of New York for dedicating substantial federal resources to vigorously defend the civil rights laws through a comprehensive investigation of possible violations of civil liberties by the Mount Vernon Police Department. Shortly after canadian pharmacy levitra value pack taking office, Westchester County District Attorney Mimi Rocah said buy levitra tablets in a statement following the announcement.

"I referred certain practices of the MVPD to DOJ canadian pharmacy levitra value pack. Today’s announcement demonstrates that parallel parts of the canadian pharmacy levitra value pack justice system operate to help create a safe environment for our communities," she said. "Out of respect for the federal investigation, my office will have no further comment at this time." Click here to sign up for Daily Voice's free daily emails and news alerts..

Federal investigators have launched a probe into a Hudson Valley police department to determine whether or not officers engaged in a pattern of discriminatory policing.US Attorney Damian Williams announced that in Westchester, the Justice Department has opened a pattern or practice investigation into the Mount Vernon Police Department.According to Williams, the investigation will assess the department’s use of force, strip and body cavity searches, and how it handles evidence.The investigation will include a comprehensive review of Mount Vernon Police Department’s systems of accountability, including complaint intake, investigation, review, disposition, and discipline.Williams said that his office and the Justice Department’s Civil Rights Division will also be cheap levitra online reaching out to community groups and members of the public to learn about their experiences with the Mount Vernon Police Department.“Police officers have tough levitra 10mg tablet price in canada jobs, and so many do their work honorably, lawfully, and with distinction, respecting the rights of the citizens they have sworn to protect,” Williams said. €œBut when officers break the law, they violate their oath and undermine a community’s trust.” City officials in Mount Vernon were notified of the cheap levitra online investigation on Friday, Dec. 3.“An effective cheap levitra online and accountable police department is a hallmark of a healthy and well-functioning democracy,” Assistant Attorney General for the Civil Rights Division Kristen Clarke said. €œThe Civil Rights Division is committed to ensuring that law enforcement agencies across our country use their authority in a manner that is constitutional, transparent, and free from discrimination.”According to Williams, “the investigation is being conducted pursuant to cheap levitra online the Violent Crime Control and Law Enforcement Act of 1994, which prohibits state and local governments from engaging in a pattern or practice of conduct by law enforcement officers that deprives individuals of rights protected by the Constitution or federal law.” Anyone who has information relevant to the investigation into the Mount Vernon Police Department has been asked to contact the Department of Justice at community.mvpd@usdoj.gov or to call (866) 985-1378."I commend the Department of Justice and the Southern District of New York for dedicating substantial federal resources to vigorously defend the civil rights laws through a comprehensive investigation of possible violations of civil liberties by the Mount Vernon Police Department. Shortly after cheap levitra online taking office, Westchester County District Attorney Mimi Rocah said in a statement discount levitra coupon following the announcement.

"I referred certain practices cheap levitra online of the MVPD to DOJ. Today’s announcement demonstrates that parallel parts of cheap levitra online the justice system operate to help create a safe environment for our communities," she said. "Out of respect for the federal investigation, my office will have no further comment at this time." Click here to sign up for Daily Voice's free daily emails and news alerts..

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Therapeutic creep in provision of hypothermia levitra mg for hypoxic ischaemic encephalopathyThree articles relate to the changing practices of UK clinicians in the provision of therapeutic hypothermia for hypoxic ischaemic encephalopathy (HIE) Buy flagyl online no prescription. Lori Hage and colleagues report the clinical characteristics of term born infants treated with therapeutic hypothermia for a diagnosis of HIE in the UK between 2010 and 2017. The data came from the National Neonatal Research Database and include infants who levitra mg were treated for 3 days or who died during this period.

There were 5201 infants who met this definition. The number of infants treated increased year on year until 2015 and then levelled out. Markers of condition at birth suggested inclusion over time of greater numbers levitra mg of infants with less severe disease.

The number of infants treated with a diagnosis of mild encephalopathy increased four-fold from 31 infants per year to 133 infants per year over the study period. There was no important change in the number levitra mg of infants treated with severe encephalopathy over the same time period. Lara Shipley and colleagues report temporal changes in the incidence of hypoxic-ischaemic encephalopathy in the UK between the time periods 2011–13 and 2014–16.

The incidence of mild and of moderate or severe HIE remained stable between epochs suggesting that there has not been diagnostic creep driving the therapeutic creep. The proportion of infants with levitra mg mild HIE who were treated with therapeutic hypothermia significantly increased over time between 2011–2013 (24.9%) and 2014–2016 (35.8%). The number of late preterm infants diagnosed with HIE also remained stable over time but again the proportion treated with hypothermia increased from 34% to 47%.

This therapeutic creep, where larger numbers of infants are cooled who do not fulfil the criteria used to select infants for enrolment in the randomised controlled trials has been observed in other health systems. On the one hand it represents levitra mg invasive treatment that is not well supported by the evidence base. Further trials are called for to determine whether hypothermia is beneficial in milder cases.

The authors also point out that there is some is some subjectivity in the assessment of levitra mg encephalopathy meaning that some clinicians don't cool borderline infants where others would classify them with more severe encephalopathy. Unrelated to these articles but on the same theme we received a viewpoint from Mohamed Ali Tagin and Alastair Gunn. They argue that the criteria used to select infants for the trials were deliberately biased towards selecting infants at highest risk (and by inference not likely to have selected all infants that stand to benefit).

The individual components of the inclusion criteria perform poorly and are levitra mg subjective. They encourage clinicians in doubt about whether an infant should be cooled to choose cooling because there is still an appreciable risk of adverse outcome and the treatment can be delivered safely, so that the potential benefits outweigh the potential harms. They argue that the limitations of the evidence should be discussed with the families levitra mg involved.

Perhaps therapeutic creep will push the trials out of reach. When new treatments are shown to be effective it is understandable that clinicians are keen to use them and this makes research more difficult before we know everything we want to know. This again is a situation that would become less likely if levitra mg we continue to work towards inclusive research models normalising routine involvement in enhancing the knowledge base.

See pages F529, F501 and F458Methods for surfactant administrationA network meta-analysis by Ioannis Bellos and colleagues of 16 RCTs and 20 observational studies including data from more than 13 000 infants, suggests that thin catheter administration of surfactant is associated with lower rates of mortality, PVL, BPD and mechanical ventilation. See page F474The cost of neonatal abstinence syndromePhilippa Rees and colleagues estimated the direct NHS costs of neonatal unit in-patient care for Neonatal Abstinence Syndrome in England between 2012 and 2017 using the National Neonatal Research Database. There were 6411 admissions with this diagnosis during the study period (1.6 per 1000 levitra mg births) and the incidence increased over time.

The direct annual cost of care was £10 440 444, with a median cost of £7715 per infant. The median time to discharge was 10.2 days and this was higher levitra mg in the 49% of infants receiving pharmacotherapy. The emerging literature suggests that changes in the model of care away from neonatal unit admission could improve patient outcomes and greatly reduce costs.

See page F494Measurement of the effect of chest compressionsResuscitation council guidance advises on the depth of chest compressions during cardiopulmonary resuscitation in the newborn. Although it levitra mg makes sense that compression depth is important this is based on indirect information and extrapolation. Marlies Bruckner and colleagues developed an automated device that could deliver controlled compression depth and investigated its effect on piglets with experimental asphyxia to asystole.

Compression depth levitra mg made an important difference to carotid blood flow and systolic blood pressure. See page F553Face mask versus nasal prong or nasopharyngeal tube for neonatal resuscitation in the delivery roomAvneet Magnat and colleagues performed a systematic review of evidence relating to the best interface for providing respiratory support in the delivery room. They identified five randomised controlled trials involving 873 infants.

There was no difference in levitra mg mortality between devices. Confidence intervals for most outcomes were wide indicating the need for more data. Difference in rates of intubation in the delivery room and need for chest compressions during initial stabilisation suggest that more data may uncover clinically important differences.

It will levitra mg be interesting to see how this meta-analysis changes after inclusion of data from the recently completed CORSAD trial. See page F561Ethics statementsPatient consent for publicationNot required.Clinical scenario‘Sarah is a baby girl born by an emergency caesarean section following a period of observation for non-reassuring cardiotocographic recordings. She was levitra mg initially ‘flat’ and received positive pressure ventilation for 3 min before establishing spontaneous breathing.

Her Apgar scores were 1, 6 and 8 at 1, 5 and 10 min, respectively. Cord pH was 7.08 and standard base excess (sBE) was −12.1. Sarah stayed with her levitra mg mother as she was breathing normally and centrally pink despite being mildly hypotonic with minimal activity.

At 10 hours of age, she started to develop recurrent seizures. Cerebral MRI showed extensive diffusion restriction patterns compatible with acute hypoxic–ischaemic insult.’Sarah is levitra mg a composite case, developed to include real events that we and others have observed. Unfortunately, many neonatal units receive similar cases every year and they often end up not offering therapeutic hypothermia, the only available treatment with proven safety and efficacy to this condition.1 The current guidelines are not inclusive and do not consider borderline cases.2 3The simple question clinicians should ask themselves, is it unreasonable to treat a newborn with perinatal asphyxia and moderate encephalopathy?.

Babies, in a situation like Sarah, may lose the opportunity to be treated with therapeutic hypothermia because they miss a single criterion from the current cooling guidelines. The selection criteria in the initial randomised controlled trials of hypothermia were developed to identify the highest risk newborns who had levitra mg been exposed to hypoxia–ischaemia. Newborns who had lower levels of risk were pragmatically excluded.

Now that the evidence for benefit is well established,1 4 we propose that those entry points ….

Therapeutic creep in provision of hypothermia cheap levitra online for hypoxic ischaemic encephalopathyThree articles relate to the changing practices of UK clinicians in the provision of therapeutic hypothermia for hypoxic ischaemic encephalopathy (HIE). Lori Hage and colleagues report the clinical characteristics of term born infants treated with therapeutic hypothermia for a diagnosis of HIE in the UK between 2010 and 2017. The data came from the National Neonatal Research Database and include infants who were treated for 3 days or who died cheap levitra online during this period. There were 5201 infants who met this definition.

The number of infants treated increased year on year until 2015 and then levelled out. Markers of condition at birth suggested inclusion over time of greater numbers of infants cheap levitra online with less severe disease. The number of infants treated with a diagnosis of mild encephalopathy increased four-fold from 31 infants per year to 133 infants per year over the study period. There was no important change in the number of infants treated with severe cheap levitra online encephalopathy over the same time period.

Lara Shipley and colleagues report temporal changes in the incidence of hypoxic-ischaemic encephalopathy in the UK between the time periods 2011–13 and 2014–16. The incidence of mild and of moderate or severe HIE remained stable between epochs suggesting that there has not been diagnostic creep driving the therapeutic creep. The proportion of infants with cheap levitra online mild HIE who were treated with therapeutic hypothermia significantly increased over time between 2011–2013 (24.9%) and 2014–2016 (35.8%). The number of late preterm infants diagnosed with HIE also remained stable over time but again the proportion treated with hypothermia increased from 34% to 47%.

This therapeutic creep, where larger numbers of infants are cooled who do not fulfil the criteria used to select infants for enrolment in the randomised controlled trials has been observed in other health systems. On the one hand it represents invasive treatment that is not well supported by cheap levitra online the evidence base. Further trials are called for to determine whether hypothermia is beneficial in milder cases. The authors also point out that cheap levitra online there is some is some subjectivity in the assessment of encephalopathy meaning that some clinicians don't cool borderline infants where others would classify them with more severe encephalopathy.

Unrelated to these articles but on the same theme we received a viewpoint from Mohamed Ali Tagin and Alastair Gunn. They argue that the criteria used to select infants for the trials were deliberately biased towards selecting infants at highest risk (and by inference not likely to have selected all infants that stand to benefit). The individual components of the inclusion criteria perform cheap levitra online poorly and are subjective. They encourage clinicians in doubt about whether an infant should be cooled to choose cooling because there is still an appreciable risk of adverse outcome and the treatment can be delivered safely, so that the potential benefits outweigh the potential harms.

They argue that the limitations of the evidence should be discussed with the families involved cheap levitra online. Perhaps therapeutic creep will push the trials out of reach. When new treatments are shown to be effective it is understandable that clinicians are keen to use them and this makes research more difficult before we know everything we want to know. This again is a situation that would become less likely cheap levitra online if we continue to work towards inclusive research models normalising routine involvement in enhancing the knowledge base.

See pages F529, F501 and F458Methods for surfactant administrationA network meta-analysis by Ioannis Bellos and colleagues of 16 RCTs and 20 observational studies including data from more than 13 000 infants, suggests that thin catheter administration of surfactant is associated with lower rates of mortality, PVL, BPD and mechanical ventilation. See page F474The cost of neonatal abstinence syndromePhilippa Rees and colleagues estimated the direct NHS costs of neonatal unit in-patient care for Neonatal Abstinence Syndrome in England between 2012 and 2017 using the National Neonatal Research Database. There were cheap levitra online 6411 admissions with this diagnosis during the study period (1.6 per 1000 births) and the incidence increased over time. The direct annual cost of care was £10 440 444, with a median cost of £7715 per infant.

The median cheap levitra online time to discharge was 10.2 days and this was higher in the 49% of infants receiving pharmacotherapy. The emerging literature suggests that changes in the model of care away from neonatal unit admission could improve patient outcomes and greatly reduce costs. See page F494Measurement of the effect of chest compressionsResuscitation council guidance advises on the depth of chest compressions during cardiopulmonary resuscitation in the newborn. Although it makes sense that compression depth cheap levitra online is important this is based on indirect information and extrapolation.

Marlies Bruckner and colleagues developed an automated device that could deliver controlled compression depth and investigated its effect on piglets with experimental asphyxia to asystole. Compression depth made an cheap levitra online important difference to carotid blood flow and systolic blood pressure. See page F553Face mask versus nasal prong or nasopharyngeal tube for neonatal resuscitation in the delivery roomAvneet Magnat and colleagues performed a systematic review of evidence relating to the best interface for providing respiratory support in the delivery room. They identified five randomised controlled trials involving 873 infants.

There was no difference in mortality between devices cheap levitra online. Confidence intervals for most outcomes were wide indicating the need for more data. Difference in rates of intubation in the delivery room and need for chest compressions during initial stabilisation suggest that more data may uncover clinically important differences. It will be interesting cheap levitra online to see how this meta-analysis changes after inclusion of data from the recently completed CORSAD trial.

See page F561Ethics statementsPatient consent for publicationNot required.Clinical scenario‘Sarah is a baby girl born by an emergency caesarean section following a period of observation for non-reassuring cardiotocographic recordings. She was cheap levitra online initially ‘flat’ and received positive pressure ventilation for 3 min before establishing spontaneous breathing. Her Apgar scores were 1, 6 and 8 at 1, 5 and 10 min, respectively. Cord pH was 7.08 and standard base excess (sBE) was −12.1.

Sarah stayed with her cheap levitra online mother as she was breathing normally and centrally pink despite being mildly hypotonic with minimal activity. At 10 hours of age, she started to develop recurrent seizures. Cerebral MRI showed extensive diffusion restriction patterns compatible with cheap levitra online acute hypoxic–ischaemic insult.’Sarah is a composite case, developed to include real events that we and others have observed. Unfortunately, many neonatal units receive similar cases every year and they often end up not offering therapeutic hypothermia, the only available treatment with proven safety and efficacy to this condition.1 The current guidelines are not inclusive and do not consider borderline cases.2 3The simple question clinicians should ask themselves, is it unreasonable to treat a newborn with perinatal asphyxia and moderate encephalopathy?.

Babies, in a situation like Sarah, may lose the opportunity to be treated with therapeutic hypothermia because they miss a single criterion from the current cooling guidelines. The selection criteria in the cheap levitra online initial randomised controlled trials of hypothermia were developed to identify the highest risk newborns who had been exposed to hypoxia–ischaemia. Newborns who had lower levels of risk were pragmatically excluded. Now that the evidence for benefit is well established,1 4 we propose that those entry points ….